Basic Information
VIS ID
TVIS44008583
Fusion event
HTLV-1-COL23A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q35.3
Reference genome
GRCh37/hg19
Start
177821139/178394138 (Hg38)
End
177821139/178394138 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5G
Target gene
COL23A1
miRNAs that regulate target gene
hsa-mir-676-5p ; hsa-mir-4474-5p ; hsa-mir-8086 ; hsa-mir-4680-5p ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-4714-3p ; hsa-mir-7151-3p ; hsa-mir-767-5p ; hsa-mir-5095 ; hsa-mir-4735-5p ; hsa-mir-1224-3p ; hsa-mir-6504-3p ; hsa-mir-501-3p ; hsa-mir-502-3p ; hsa-mir-4438 ; hsa-mir-32-3p
Nearest miRNA
hsa-mir-10397/Upstream/1764638; hsa-mir-1229/Downstream/1404140;
Nearest TSS
ENST00000502646/Upstream/43271; ENST00000520377/Downstream/168588;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/56798, chr5-CpG: 191/Downstream/713
Upstream sequence
AAGGAAGCAGGTGCTCAGTGTGGCCACAGACTATCAAACCTGGAGCGAAAGACCTGGGAGGGCAGGAGGAAGGGAAGCTTCAGGGAGGAAGCAGAGGCAG
Downstream sequence
GACAGGCAAGGAGGAGGCCCAGGGCTCCAGCACAGGCAGAGCATACAGTCACTATCTGCACCTGTCCTGCCCTGCAGGCCTGGAGCCTCCTGAGGGCAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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