Basic Information
VIS ID
TVIS44008595
Fusion event
HTLV-1-GRM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.3
Reference genome
GRCh37/hg19
Start
146359534/146038398 (Hg38)
End
146359534/146038398 (Hg38)
Orient
-
Location type
Intronic
Target gene
GRM1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-1281 ; hsa-mir-6862-5p ; hsa-mir-4253 ; hsa-mir-3945 ; hsa-mir-5787 ; hsa-mir-4505 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-3187-5p ; hsa-mir-5189-5p ; hsa-mir-1285-3p ; hsa-mir-5193 ; hsa-mir-660-3p ; hsa-mir-5196-3p
Nearest miRNA
hsa-mir-10398/Upstream/5354515; hsa-mir-1202/Downstream/5064277;
Nearest TSS
ENST00000381078/Upstream/8912; ENST00000367495/Downstream/505295;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/8754, chr6-CpG: 44/Downstream/395941
Nearest cancer related gene
GRM1(OG, No orient, 0)
Upstream sequence
GAGAAGGGTGGCTAGAGTTGAAATCCAGAGATCTGGAATAGGATTGACTCAAGGGATTAATAGAATTAGGCATGCTTAGAGAGCTATCAGGGTGAAGTAT
Downstream sequence
ACAGAAAACAGTCCCCTAAGTTTATTATACAGATAAGATGCAACAGTGCTCCATATAGGGCTAGGTAGATGTAATAGATGTAAGATGTCATTATTGTTGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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