Basic Information
VIS ID
TVIS44008599
Fusion event
HTLV-1-ABCB1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.12
Reference genome
GRCh37/hg19
Start
87223810/87594494 (Hg38)
End
87223810/87594494 (Hg38)
Orient
+
Location type
Intronic
Target gene
ABCB1
miRNAs that regulate target gene
hsa-mir-451a ; hsa-mir-129-5p ; hsa-mir-508-5p ; hsa-mir-223-3p ; hsa-mir-186-5p ; hsa-mir-34b-3p ; hsa-mir-1-3p ; hsa-mir-491-3p ; hsa-mir-21-5p ; hsa-mir-9-3p ; hsa-mir-495-3p ; hsa-mir-873-5p
Nearest miRNA
hsa-mir-10525/Upstream/11679225; hsa-mir-10399/Downstream/4609521;
Nearest TSS
ENST00000635602/Upstream/44336; ENST00000497788/Downstream/6579;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/118505, chr7-CpG: 34/Downstream/5741
Upstream sequence
TAAAGCTCCATATTTTTATTCTTTTGTGCCTTAAAATGAATTATTGATAACATTGCCTCTATATAGTAGGTCTGTTAAATTTTCTAAAATATAAGACTCC
Downstream sequence
TAAGGTTTAAAAAAATTTAACTACAAATAATAAAAACTGAAAGTCTCAAAGTGACAGCACTGAAATCCTGGGGATAAATACAACTTTAACCTAAACGCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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