VISDB - VIS Detail

Basic Information

VIS ID

TVIS44008604

Fusion event

HTLV-1-EIF4EBP1 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr8

Cytoband

p11.23

Reference genome

GRCh37/hg19

Start

37894001/38036483 (Hg38)

End

37894001/38036483 (Hg38)

Orient

Location type

Intronic

Target gene

EIF4EBP1

miRNAs that regulate target gene

hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-124-3p ; hsa-mir-138-5p ; hsa-mir-202-3p ; hsa-mir-650 ; hsa-mir-3173-3p ; hsa-mir-3612 ; hsa-mir-3692-5p ; hsa-mir-4443 ; hsa-mir-4457 ; hsa-mir-4686 ; hsa-mir-5582-5p ; hsa-mir-6071 ; hsa-mir-6891-5p ; hsa-mir-7847-3p ; hsa-mir-93-3p ; hsa-mir-1273e ; hsa-mir-6894-5p ; hsa-mir-4722-5p ; hsa-mir-4459 ; hsa-mir-6165 ; hsa-mir-4711-5p ; hsa-mir-7112-3p ; hsa-mir-194-3p ; hsa-mir-5693 ; hsa-mir-5094 ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-937-5p ; hsa-mir-5702 ; hsa-mir-4679 ; hsa-mir-4677-3p ; hsa-mir-5186 ; hsa-mir-4325 ; hsa-mir-7703 ; hsa-mir-6720-5p ; hsa-mir-6512-3p ; hsa-mir-6508-3p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-661 ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-25-3p ; hsa-mir-508-5p

Nearest miRNA

hsa-mir-124-1/Upstream/8079135; hsa-mir-10400/Downstream/3234565;

Nearest TSS

ENST00000518652/Upstream/6142; ENST00000520657/Downstream/10856;

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/5171, chr8-CpG: 91/Downstream/68448

Upstream sequence

gcgcctgtaatcccagctacacaggaggctgaggcacgagactcactcgaacGATTCTGGGTGACAAGAGTGAAACTCCGTCTCAAAGAAAAAAGAGAGA

Downstream sequence

GAGTTTGATTTTTTTGCTTCCTAAAAGACCAAAAAAGTCCTTCATTGCCAAATCTGAGGAAAAAGGGTCAGCAGAGCAATACCATATTTATCCATTGACA

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.