Basic Information
VIS ID
TVIS44008610
Fusion event
HTLV-1-AZIN1-AS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
103901523/102889295 (Hg38)
End
103901523/102889295 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA8A
Target gene
AZIN1-AS1
Nearest miRNA
hsa-mir-12123/Upstream/763780; hsa-mir-10400/Downstream/265319;
Nearest TSS
ENST00000518652/Upstream/9379; ENST00000523791/Downstream/2581;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/24439, chr8-CpG: 19/Downstream/131815
Upstream sequence
actccagtctgggcaacagagcaagactccgtctcaaaaaaaaaaaTTATTTACTATAGAACTTGTATATGTATTCTTGAAAAAGAATTCAAAGGGAGAA
Downstream sequence
CCTCTTCCCAGGGTCACAGAGTGATCAGTGCCACAGCTTGGACTTGGAGCCTTAGCTTATCTGCCATCTTCCTACTGCATCAAAGCAGAGATTGCCACGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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