Basic Information
VIS ID
TVIS44008624
Fusion event
HTLV-1-NTRK2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
87358650/84743735 (Hg38)
End
87358650/84743735 (Hg38)
Orient
+
Location type
Intronic
Target gene
NTRK2
miRNAs that regulate target gene
hsa-mir-200c-3p ; hsa-mir-335-5p ; hsa-mir-204-5p ; hsa-mir-581 ; hsa-mir-145-3p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-101-2/Upstream/773878; hsa-let-7a-1/Downstream/4002101;
Nearest TSS
ENST00000422679/Upstream/73075; ENST00000416045/Downstream/835290;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/72946, chr9-CpG: 42/Downstream/778959
Upstream sequence
GACCCTTTCCCAGTTAATTCAAGACTTTAAAAATGTCATCTTCCTGTTAGCCTCAGATCCTACTTTGGATCTTTTGGCCAAAATGTCATGATACTAAACT
Downstream sequence
ATAGACACTTGAATGATTTAAATTTTGCAGACGTAGTTGGCTATAACATGAAGAGGGAAAACTAAACAAATAAATGATATCCATTAGTGTTTAAAATTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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