Basic Information
VIS ID
TVIS44008634
Fusion event
HTLV-1-TENM1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q25
Reference genome
GRCh37/hg19
Start
123513899/124380049 (Hg38)
End
123513899/124380049 (Hg38)
Orient
+
Location type
UTR3
Target gene
TENM1
miRNAs that regulate target gene
hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-3653-3p ; hsa-mir-3658 ; hsa-mir-4778-3p ; hsa-mir-4698 ; hsa-mir-5680 ; hsa-mir-7154-5p ; hsa-mir-8060 ; hsa-mir-335-3p ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-5696 ; hsa-mir-6516-3p ; hsa-mir-4536-5p ; hsa-mir-6876-3p ; hsa-mir-626 ; hsa-mir-215-3p
Nearest miRNA
hsa-let-7f-2/Upstream/3008996; hsa-mir-105-1/Downstream/9789329;
Nearest TSS
ENST00000429181/Upstream/33460; ENST00000632600/Downstream/117094;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/46702, chrX-CpG: 17/Downstream/822872
Upstream sequence
CACAACAATATGGCATTTACTTTAACAAGCAAGGAGGAATAATCAAGAAGGAAGGGCAATTGGGTCCTCACTCTAGGAGATGGTGGCTGAAGACATTTTA
Downstream sequence
CACCTGTTTTTAAGTTTCCTATAACAGATCTGGAAAACGTCAAAGGGCTGGCAGTCTTTCGAAAGGCAAGTTTCAGATACTATTGCACCACCTATTCAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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