Basic Information
VIS ID
TVIS44008637
Fusion event
HTLV-1-TBL1Y integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrY
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
6793100/6925059 (Hg38)
End
6793100/6925059 (Hg38)
Orient
-
Location type
Intronic
Target gene
TBL1Y
Nearest miRNA
hsa-mir-3690-2/Upstream/2318831; hsa-mir-12120/Downstream/6554118;
Nearest TSS
ENST00000430575/Upstream/14373; ENST00000413466/Downstream/776188;
Nearest CpG islands
None/Target, chrY-CpG: 62/Upstream/13072, chrY-CpG: 170/Downstream/348421
Upstream sequence
GTCTGGGAGACATGATTTGGTTTAATTCCCATTTTGATTTTGGAAAAAAGTCACATTTGGCTTGCTTTGTTTCACCAAGACACACTGGTGGTTCTGTCCC
Downstream sequence
AATTTCAGCCACTTCCAGTGATCTGTATTAGGATACTTCAAAAACCCTAACCAGAAGAGGCAATCTTTGAGGTGCACCCAGCTCAGAAGCTGGTGAAAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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