Basic Information
VIS ID
TVIS44008643
Fusion event
HTLV-1-chr1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q41
Reference genome
GRCh37/hg19
Start
224075988/223888286 (Hg38)
End
224075988/223888286 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-101-1/Upstream/3687667; hsa-mir-1182/Downstream/368754;
Nearest TSS
ENST00000473358/Upstream/42314; ENST00000618397/Downstream/105976;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/41725, chr1-CpG: 63/Downstream/104274
Nearby gene
TP53BP2(-42314) ;
Nearest cancer related gene
TP53BP2(TSG, -42314) ;
Upstream sequence
ACGCAGGTGACGTATACCCTACAGCCATGGTGCTTTCCTTTCCGGTTTCATGCTTAGCAAAGAGCCCTCTGATTAATGATGCGTCACCCGAGAGCCCGTC
Downstream sequence
CACTAGAAATGATGGCAATGTTCCTCCTAAGGGCACAGATTGGTGACCCAGGCAATCTGTCACTGTAAGGGGAAATCCCTGTTGCAAATCATTCTGCTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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