Basic Information
VIS ID
TVIS44008683
Fusion event
HTLV-1-CA5A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q24.2
Reference genome
GRCh37/hg19
Start
87930569/87896963 (Hg38)
End
87930569/87896963 (Hg38)
Orient
+
Location type
Intronic
Target gene
CA5A
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-11401/Upstream/42999; hsa-mir-4722/Downstream/571955;
Nearest TSS
ENST00000527434/Upstream/4695; ENST00000612301/Downstream/39553;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/4984, chr16-CpG: 23/Downstream/17949
Upstream sequence
tcctgacctcaggtgatccgcccgcctcagcctcccacagtgctgggattataggcgtgagccacGCTCtgttcctggttttgtcttctttctcttaaac
Downstream sequence
aggaccccacattttatgagcgtcaagccccacccagcctaactccgcccttgCTTTGTCCTCTTAGAGTCTCAGTTTCCCCAGGTGTACGACAGGCAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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