Basic Information
VIS ID
TVIS44008695
Fusion event
HTLV-1-AFTPH integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p14
Reference genome
GRCh37/hg19
Start
64781749/64554615 (Hg38)
End
64781749/64554615 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
AFTPH
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-181a-5p ; hsa-mir-21-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-133a-3p ; hsa-mir-183-3p ; hsa-mir-2278 ; hsa-mir-4452
Nearest miRNA
hsa-mir-1301/Upstream/29050; hsa-mir-10b/Downstream/1803634;
Nearest TSS
ENST00000437798/Upstream/1739; ENST00000422803/Downstream/14558;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/29752, chr2-CpG: 79/Downstream/54457
Upstream sequence
CTTTCCAAAGTCTTTGTAATTGAAATACTTATATTTCATTGCCTTGATAACTTTGAGACAGTAAGATATTAGAGAAATTATGGTATTACCAGTTGGTGTG
Downstream sequence
CATAGCTAATCGCTTTTTAGTTGGCTTTTGTGTCAAAGTAGTTTAATTTGCTAATTCAGTTATTACATGGTTTAGCTAATGTGTATTATTCCTATTGAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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