Basic Information
VIS ID
TVIS44008704
Fusion event
HTLV-1-ZNF831 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr20
Cytoband
q13.32
Reference genome
GRCh37/hg19
Start
57727550/59152495 (Hg38)
End
57727550/59152495 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF831
miRNAs that regulate target gene
hsa-mir-182-5p ; hsa-mir-6792-3p ; hsa-mir-4691-5p ; hsa-mir-4470 ; hsa-mir-5193 ; hsa-mir-4667-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-6865-3p ; hsa-mir-34b-3p
Nearest miRNA
hsa-mir-103a-2/Upstream/334182; hsa-mir-1-1/Downstream/1155979;
Nearest TSS
ENST00000382410/Upstream/29091; ENST00000371030/Downstream/38525;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/109328, chr20-CpG: 114/Downstream/38846
Nearby gene
ZNF831(+38525) ;
Upstream sequence
GGTTTGTGGATCAAGAGAAGGAAGGGAATTCCTGGCTGAGGAACAGCATAAGCAAAGTGTGGAGGAGAGCCTGGGGGCCTTTGGTTTGATTGGAGGGTGC
Downstream sequence
ACGCATCCATCCGTGCATGCCGGGGCAGTGGGCTTGGAGCTGGCGAATAGGGTACAAAGTCCCTGCTCTTTTGGGGATTGCAACGTTAAGCAAGTAATGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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