Basic Information
VIS ID
TVIS44008712
Fusion event
HTLV-1-THRB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p24.2
Reference genome
GRCh37/hg19
Start
24439601/24398110 (Hg38)
End
24439601/24398110 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA3A
Target gene
THRB
miRNAs that regulate target gene
hsa-mir-27a-3p ; hsa-mir-204-5p ; hsa-mir-155-5p ; hsa-mir-425-5p ; hsa-mir-452-5p ; hsa-mir-4677-3p ; hsa-mir-4679 ; hsa-mir-3161 ; hsa-mir-3689f ; hsa-mir-3689e ; hsa-mir-3689b-5p ; hsa-mir-3689a-5p ; hsa-mir-3926 ; hsa-mir-4778-5p ; hsa-mir-4753-5p ; hsa-mir-6794-3p ; hsa-mir-3152-5p ; hsa-mir-6836-3p ; hsa-mir-15b-3p ; hsa-mir-4264 ; hsa-mir-4797-3p ; hsa-mir-6809-3p ; hsa-mir-4753-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-1236-3p ; hsa-mir-6515-3p ; hsa-mir-101-3p ; hsa-mir-200a-3p ; hsa-mir-1238-5p ; hsa-mir-129-5p ; hsa-mir-3659 ; hsa-mir-4658 ; hsa-mir-4758-5p ; hsa-mir-574-5p ; hsa-mir-6790-5p ; hsa-mir-8055 ; hsa-mir-8081 ; hsa-mir-1537-5p ; hsa-mir-320a ; hsa-mir-320b ; hsa-mir-320c ; hsa-mir-320d ; hsa-mir-3607-3p ; hsa-mir-4429 ; hsa-mir-4633-3p ; hsa-mir-4793-5p ; hsa-mir-5002-5p ; hsa-mir-5196-3p ; hsa-mir-6500-5p ; hsa-mir-6870-3p ; hsa-mir-6874-5p ; hsa-mir-9-3p
Nearest miRNA
hsa-mir-12127/Upstream/4260469; hsa-let-7g/Downstream/1266763;
Nearest TSS
ENST00000440867/Upstream/49208; ENST00000455576/Downstream/88485;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/451580, chr3-CpG: 135/Downstream/96243
Nearest cancer related gene
THRB(TSG, No orient, 0)
Upstream sequence
ACAAAACAATAATTCAAAGCCAAAAGTATCTTCTATCTTATACTATAACTGCTTATGTATCAATGGACATAATGATGTTGAATAGACAGACTGAAAATAC
Downstream sequence
TTGGTAAATACCAGTAATTAACTCTCATTTTTTAAAAAAATGGATTGAGGTGGGGCAAAGAAGCATAGAAGAGGGAAAATGTGGGCAATCAGAAACCTAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate