Basic Information
VIS ID
TVIS44008714
Fusion event
HTLV-1-HIGD1A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
42831187/42789695 (Hg38)
End
42831187/42789695 (Hg38)
Orient
-
Location type
Intronic
Target gene
HIGD1A
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-16-5p ; hsa-mir-1301-3p ; hsa-mir-450b-5p ; hsa-mir-106a-3p ; hsa-mir-4291 ; hsa-mir-761 ; hsa-mir-3619-5p ; hsa-mir-922 ; hsa-mir-214-3p ; hsa-mir-545-3p ; hsa-mir-3617-3p ; hsa-mir-3074-3p ; hsa-mir-548p ; hsa-mir-15a-5p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-6838-5p ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-12127/Upstream/3651429; hsa-let-7g/Downstream/1324517;
Nearest TSS
ENST00000440867/Upstream/16442; ENST00000565749/Downstream/14738;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/16294, chr3-CpG: 85/Downstream/14249
Upstream sequence
TTCACGAAAGATGAAACTATGTGAACATCTGAATAGTAAAAGTAAATTAGAATATAGTTCAGACACCAAAAGCAAATACAAATTGTACTTAGTGTTAAAA
Downstream sequence
CACTATAAATATTCCATTTTTAATTtttatctatttatttatttatttagagacagggtcttgctctgtcacccaggctgtagtggcatgatcatggttc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate