Basic Information
VIS ID
TVIS44008716
Fusion event
HTLV-1-MECOM integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.2
Reference genome
GRCh37/hg19
Start
168835109/169117321 (Hg38)
End
168835109/169117321 (Hg38)
Orient
-
Location type
Intronic
Target gene
MECOM
miRNAs that regulate target gene
hsa-mir-22-3p
Nearest miRNA
hsa-let-7g/Upstream/565372; hsa-mir-1224/Downstream/1305782;
Nearest TSS
ENST00000440867/Upstream/114247; ENST00000480669/Downstream/5351;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/866979, chr3-CpG: 39/Downstream/28921
Nearest cancer related gene
MECOM(OG, No orient, 0)
Upstream sequence
TTATTGCCTCTCCCCTTGGGGAAAAAGCCTGTGACTGCCCTGCTATTATTTAATTGGTATTATATCATATGCTCTCATCATTCACACATCAAAGCCACAC
Downstream sequence
AACAATGCACATTGTGTATTCTGAGACTTTTTTTAACAATCATTTTCATGATTTGAGAAAGACTGACATAATTTACAATGGCTCTATTTTAAGCCTGCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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