Basic Information
VIS ID
TVIS44008738
Fusion event
HTLV-1-CCND3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
41967439/41999701 (Hg38)
End
41967439/41999701 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
CCND3
miRNAs that regulate target gene
hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-34a-5p ; hsa-mir-195-5p ; hsa-mir-138-5p ; hsa-mir-615-3p ; hsa-mir-324-5p ; hsa-mir-27b-3p ; hsa-let-7b-5p ; hsa-mir-503-5p ; hsa-mir-28-5p ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-497-5p ; hsa-mir-218-5p ; hsa-mir-7106-5p ; hsa-mir-6722-3p ; hsa-mir-765 ; hsa-mir-6836-5p ; hsa-mir-1909-3p ; hsa-mir-6132 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-15b-5p ; hsa-mir-15b-3p
Nearest miRNA
hsa-mir-10398/Upstream/266091; hsa-mir-10524/Downstream/1434841;
Nearest TSS
ENST00000381078/Upstream/57853; ENST00000412701/Downstream/30352;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/57728, chr6-CpG: 48/Downstream/48804
Upstream sequence
ataaagctaaacttggtggctcatggctcacacctataatcccagcacttagggaagccaaggctggaggatcacttgagcccaggagtttgagatcagc
Downstream sequence
ctgtcaacatagtgagacgtcatctctacaaaaaatttaaaaggccggacatggtggtatgcacctacagtcccagcttctttggaggctgaggcaggag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate