Basic Information
VIS ID
TVIS44008739
Fusion event
HTLV-1-TRERF1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p21.1
Reference genome
GRCh37/hg19
Start
42375980/42408242 (Hg38)
End
42375980/42408242 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
TRERF1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-30b-5p ; hsa-mir-101-3p ; hsa-mir-324-5p ; hsa-mir-342-3p ; hsa-mir-377-3p ; hsa-mir-3120-3p ; hsa-mir-603 ; hsa-mir-8485
Nearest miRNA
hsa-mir-10398/Upstream/674632; hsa-mir-10524/Downstream/1026300;
Nearest TSS
ENST00000381078/Upstream/190377; ENST00000372903/Downstream/43019;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/148492, chr6-CpG: 18/Downstream/43530
Upstream sequence
ATAACATGTCTTATCCATTGGTTTATTACAACTGTTTCCCTCTTCCATTAACTTCGCtatataaataaatatatatatatatatatgtgtgtgtgtatgt
Downstream sequence
atatatacatacacatgtgtgtgtatgtatatatacatacacatgtgtgtgtatgtatatatacatactcatgtgtgtgtatatatatatatacatacac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate