Basic Information
VIS ID
TVIS44008741
Fusion event
HTLV-1-EFHC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
52341408/52476610 (Hg38)
End
52341408/52476610 (Hg38)
Orient
+
Location type
Intronic
Target gene
EFHC1
miRNAs that regulate target gene
hsa-mir-17-5p ; hsa-mir-190a-3p ; hsa-mir-6832-5p ; hsa-mir-4732-5p ; hsa-mir-7852-3p ; hsa-mir-3668 ; hsa-mir-5011-5p ; hsa-mir-3163 ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-1277-5p ; hsa-mir-493-5p ; hsa-mir-3177-5p ; hsa-mir-5580-3p ; hsa-mir-514b-5p ; hsa-mir-513c-5p ; hsa-mir-6868-3p ; hsa-mir-6881-3p ; hsa-mir-6780a-3p ; hsa-mir-4755-3p ; hsa-mir-7111-3p ; hsa-mir-7110-3p ; hsa-mir-520f-5p ; hsa-mir-3667-3p ; hsa-mir-6734-3p ; hsa-mir-6769b-3p ; hsa-mir-4723-3p ; hsa-mir-3183 ; hsa-mir-484 ; hsa-mir-3155b ; hsa-mir-3155a ; hsa-mir-3922-5p ; hsa-mir-4753-5p
Nearest miRNA
hsa-mir-10398/Upstream/327569; hsa-mir-10524/Downstream/800383;
Nearest TSS
ENST00000381078/Upstream/8216; ENST00000636169/Downstream/7007;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/56155, chr6-CpG: 112/Downstream/100018
Upstream sequence
gaaatatggtaactttaagggaagaaatccagcagaaaccttaaccaagtgatcaaggtcagtgttatccataataagatatattgacatcataaactcc
Downstream sequence
ctggtatacactaaagacatggtatcttttctgggttacttttgccaaaaatgcaaaaatgagatgcctgaggaacattcaagaaaataattgatgagta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate