Basic Information
VIS ID
TVIS44008745
Fusion event
HTLV-1-AGMO integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p21.2
Reference genome
GRCh37/hg19
Start
15302433/15262808 (Hg38)
End
15302433/15262808 (Hg38)
Orient
+
Location type
Intronic
Target gene
AGMO
miRNAs that regulate target gene
hsa-mir-5698 ; hsa-mir-6738-3p ; hsa-mir-6836-3p ; hsa-mir-5001-3p ; hsa-mir-4727-5p ; hsa-mir-143-5p ; hsa-mir-6829-3p ; hsa-mir-6791-3p ; hsa-mir-6778-3p ; hsa-mir-6499-3p ; hsa-mir-6777-3p ; hsa-mir-483-3p ; hsa-mir-3145-5p ; hsa-mir-3680-5p ; hsa-mir-498 ; hsa-mir-4279 ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p
Nearest miRNA
hsa-mir-339/Upstream/8195763; hsa-mir-10399/Downstream/2864412;
Nearest TSS
ENST00000635602/Upstream/196601; ENST00000451240/Downstream/103379;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1271220, chr7-CpG: 17/Downstream/1136689
Upstream sequence
tactataaggcccataaaaatgggcacatatatcaatggaacaaaacagagaacccagaaataaagccaaatacttacagccaactgatcttcgacaaag
Downstream sequence
catacaaaaacataaagtggaaaaggttaccctactcaacaaatggttctgggatacctggcaagccacatgtagaagaatgaaactggatccacatctc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate