Basic Information
VIS ID
TVIS44008749
Fusion event
HTLV-1-PPP1R9A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
94672182/95042870 (Hg38)
End
94672182/95042870 (Hg38)
Orient
-
Location type
Intronic
Target gene
PPP1R9A
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-130b-3p ; hsa-mir-33a-5p ; hsa-mir-181a-5p ; hsa-mir-3121-3p
Nearest miRNA
hsa-mir-10525/Upstream/1325865; hsa-mir-10399/Downstream/1176792;
Nearest TSS
ENST00000635602/Upstream/132787; ENST00000608730/Downstream/171462;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/134705, chr7-CpG: 19/Downstream/281587
Upstream sequence
ACAAAATACAATGGTTTTTGTATCATCTACATGTTAAAATAAATTTCATGTTTTGAAATAATCCACACATTGAAATAAACAGAGTTTAGCTGATGACTCT
Downstream sequence
CACTTTGAAATTTTATTTTTCTGGTACATCTAAAAGTATATTTTTGTTAAAAAAAAAAGTCCCTTTAAGACAGATTTTAGGTACTCCATTTGCTACACAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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