Basic Information
VIS ID
TVIS44008766
Fusion event
HTLV-1-AFF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q28
Reference genome
GRCh37/hg19
Start
148065569/148984039 (Hg38)
End
148065569/148984039 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRAXE ; FRAXF
Target gene
AFF2
miRNAs that regulate target gene
hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-3175 ; hsa-mir-8085 ; hsa-mir-6731-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4786-5p ; hsa-mir-6794-5p ; hsa-mir-4716-3p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-6502-3p ; hsa-mir-877-5p ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6859-5p ; hsa-mir-3916 ; hsa-mir-3125 ; hsa-mir-603 ; hsa-mir-8485 ; hsa-mir-2113 ; hsa-mir-3177-5p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-511-3p ; hsa-mir-4783-5p ; hsa-mir-3180-5p ; hsa-mir-525-5p ; hsa-mir-520a-5p ; hsa-mir-22-5p ; hsa-mir-5584-3p ; hsa-mir-488-5p ; hsa-mir-4773 ; hsa-mir-148a-5p ; hsa-mir-933 ; hsa-mir-1976 ; hsa-mir-26a-1-3p ; hsa-mir-26a-2-3p ; hsa-mir-3653-5p ; hsa-mir-370-3p ; hsa-mir-4279 ; hsa-mir-4720-3p ; hsa-mir-4804-3p ; hsa-mir-548aa ; hsa-mir-548ap-3p ; hsa-mir-548as-3p ; hsa-mir-548at-3p ; hsa-mir-548ay-3p ; hsa-mir-548t-3p ; hsa-mir-645 ; hsa-mir-6893-3p
Nearest miRNA
hsa-let-7f-2/Upstream/1699311; hsa-mir-105-1/Downstream/1243965;
Nearest TSS
ENST00000429181/Upstream/264948; ENST00000448332/Downstream/514227;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/482276, chrX-CpG: 17/Downstream/486981
Upstream sequence
agagtgaaatagacaaaaaaaaaaaaaaactgccctcatcaaggtcacattctgttgaaggagaaagataacaacaaacatgtggcatactaggttgtgg
Downstream sequence
gaagtgtcatggagaaaactgaaacaaggaaggcaggcagaaagggctgctgaggataggggagggagcagtggtaccatgctgaatcttgagtagggat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate