Basic Information
VIS ID
TVIS44008785
Fusion event
HTLV-1-EIF4G3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.12
Reference genome
GRCh37/hg19
Start
21479854/21153361 (Hg38)
End
21479854/21153361 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
EIF4G3
miRNAs that regulate target gene
hsa-mir-375 ; hsa-mir-24-3p ; hsa-mir-16-5p ; hsa-mir-221-3p ; hsa-mir-17-5p ; hsa-mir-3613-3p ; hsa-mir-543 ; hsa-mir-136-5p ; hsa-mir-377-5p ; hsa-mir-218-5p ; hsa-mir-548c-3p ; hsa-mir-4724-3p ; hsa-mir-6813-3p ; hsa-mir-3200-3p
Nearest miRNA
hsa-mir-12136/Upstream/164929; hsa-mir-101-1/Downstream/1112878;
Nearest TSS
ENST00000473358/Upstream/41751; ENST00000416959/Downstream/21376;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/365733, chr1-CpG: 77/Downstream/23261
Upstream sequence
TAGACAGACAAAAGTCTTCACTCATCTAGAAGATTCTAACGGCATTCTGAATAGCACTATCATTCTTTTAACTATCTACTATGACAGCTACCACAGTAAC
Downstream sequence
ATTTATTTTTAATAGCTGAGACCATTTGAgaaggaggtgagttaaaagatttccataatccattctaaccctcgcattctaagattctGGTTCTCTTTAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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