Basic Information
VIS ID
TVIS44008802
Fusion event
HTLV-1-DCTN2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
57936870/57543087 (Hg38)
End
57936870/57543087 (Hg38)
Orient
-
Location type
Intronic
Target gene
DCTN2
miRNAs that regulate target gene
hsa-mir-502-3p ; hsa-mir-149-5p ; hsa-mir-18a-5p
Nearest miRNA
hsa-mir-1228/Upstream/23828; hsa-let-7i/Downstream/205531;
Nearest TSS
ENST00000382841/Upstream/4521; ENST00000552227/Downstream/4033;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/20067, chr12-CpG: 35/Downstream/3693
Upstream sequence
AAACTGATAAAATTAAAGTTGAAAATAAACTGAAGATTAAGGCGGAGAATGCTGTTGTCAGGGGTTAAGAAGGTGACTGAggctgggcatggtggctcac
Downstream sequence
gtctgtaatcccagcactttgggaggccaagacaggcggatcacgaggtcaggagatcgagaccatcctggctaacacatgaaaccccgtctctactaaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate