Basic Information
VIS ID
TVIS44008812
Fusion event
HTLV-1-STRN3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q12
Reference genome
GRCh37/hg19
Start
31479349/31010143 (Hg38)
End
31479349/31010143 (Hg38)
Orient
-
Location type
Intronic
Target gene
STRN3
miRNAs that regulate target gene
hsa-mir-125b-5p ; hsa-mir-6890-3p ; hsa-mir-5003-3p ; hsa-mir-548d-3p ; hsa-mir-548h-3p ; hsa-mir-548z ; hsa-mir-548ac ; hsa-mir-548bb-3p ; hsa-mir-507 ; hsa-mir-557 ; hsa-mir-450b-5p ; hsa-mir-3680-3p ; hsa-mir-155-5p ; hsa-mir-142-3p ; hsa-mir-500a-3p ; hsa-mir-3926 ; hsa-mir-767-5p ; hsa-mir-548ay-3p ; hsa-mir-548at-3p ; hsa-mir-4275 ; hsa-mir-7977 ; hsa-mir-383-3p ; hsa-mir-6858-3p ; hsa-mir-24-3p ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-2276-3p ; hsa-mir-1304-3p ; hsa-mir-342-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-564 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-593-3p ; hsa-mir-6879-3p ; hsa-mir-4294 ; hsa-mir-215-3p ; hsa-mir-6773-3p ; hsa-mir-500b-3p
Nearest miRNA
hsa-mir-208a/Upstream/3376865; hsa-mir-1185-1/Downstream/4503;
Nearest TSS
ENST00000550708/Upstream/45634; ENST00000555417/Downstream/14963;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/134875, chr14-CpG: 113/Downstream/15445
Upstream sequence
agtgagccatgattgatagcatcactgaactcaagcctgggtgacggtatgagaccctgtctctaaaaaacaaaagtaaaataaaaaacaaaaGAAGAAA
Downstream sequence
TCAGTAAAAAAGGAAATAGGAAAAAGACAAACTAGTCTATAAATTCATTAAAACTAACATATTTGCTTTGTTTTATAACTATTTTTtctttttattatta
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate