Basic Information
VIS ID
TVIS44008818
Fusion event
HTLV-1-CYP19A1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
51526255/51234058 (Hg38)
End
51526255/51234058 (Hg38)
Orient
-
Location type
Intronic
Target gene
CYP19A1
miRNAs that regulate target gene
hsa-mir-378a-3p ; hsa-let-7f-5p ; hsa-mir-106a-5p ; hsa-mir-19b-3p ; hsa-mir-335-5p ; hsa-mir-98-5p ; hsa-mir-515-5p
Nearest miRNA
hsa-mir-10393/Upstream/873648; hsa-mir-11181/Downstream/8132;
Nearest TSS
ENST00000557528/Upstream/11704; ENST00000559672/Downstream/8953;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/138500, chr15-CpG: 69/Downstream/107469
Upstream sequence
TGCCTGACTTCTCCCCTGAAGTTCTGCAGCCCCTACTACTTTGGGACGAAGCTGGTTGGAAAAGTTGGACCATAATTTCTACACAGTTGTAATGACTACA
Downstream sequence
GACCTCAAACTTTTCAAAAGAAAAAAAAAATCTGGCAAACTATTCAAATAAAAATAAAAATCTTTCTGAGGTCCAATGGGGTCTTTTCAAGAGGTACGGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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