Basic Information
VIS ID
TVIS44008822
Fusion event
HTLV-1-PLXDC1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
q12
Reference genome
GRCh37/hg19
Start
37251361/39095108 (Hg38)
End
37251361/39095108 (Hg38)
Orient
-
Location type
Intronic
Target gene
PLXDC1
miRNAs that regulate target gene
hsa-mir-106a-3p ; hsa-mir-670-5p ; hsa-mir-4319 ; hsa-mir-125b-5p ; hsa-mir-125a-5p ; hsa-mir-4732-3p ; hsa-mir-345-3p ; hsa-mir-4661-3p ; hsa-mir-4713-5p ; hsa-mir-2116-3p ; hsa-mir-532-3p ; hsa-mir-150-5p ; hsa-mir-186-3p ; hsa-mir-3613-3p ; hsa-mir-3121-3p ; hsa-mir-4524a-3p ; hsa-mir-5739 ; hsa-mir-5091 ; hsa-mir-4524b-3p ; hsa-mir-1468-5p
Nearest miRNA
hsa-mir-1180/Upstream/180066; hsa-mir-10226/Downstream/202292;
Nearest TSS
ENST00000595228/Upstream/15838; ENST00000579256/Downstream/12360;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/176264, chr17-CpG: 51/Downstream/56319
Upstream sequence
CTTTTCAAGGGAACTGAGTTCGAGGATAGAGACACAAGTGGCAGCCAGGGAAGCCAAGTCTCCTAGAAACTTCACACCAGGCTCTAGGGATGGGTTTCCC
Downstream sequence
CACCATCCGGGCTGGGGGGCAGAGTTGGGGATGTGCCCCAAGCATGGGTGCAGCCAGGGATGCCAGCTGTCCTCTGAAAATACAGTCCTTCCAGCGGAGT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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