Basic Information
VIS ID
TVIS44008823
Fusion event
HTLV-1-ARHGAP28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
p11.31
Reference genome
GRCh37/hg19
Start
6895594/6895595 (Hg38)
End
6895594/6895595 (Hg38)
Orient
+
Location type
Intronic
Target gene
ARHGAP28
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-196a-5p ; hsa-mir-98-5p
Nearest miRNA
hsa-mir-3976/Upstream/521170; hsa-mir-1-2/Downstream/3863989;
Nearest TSS
ENST00000575820/Upstream/20571; ENST00000579796/Downstream/1165;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/165557, chr18-CpG: 27/Downstream/24997
Upstream sequence
agcaagcttggcgccttctgaatgctgtgagagaagcacctgcttcttgcccctctcctcacttttggcgatgccagtaatcctcggcattcctcagctg
Downstream sequence
gtctcagcctccatcttcacatggtgttctttcttgtgtctccatgtctcttctcctcttacaaggatgcaagtcacttggattaagggcactccctact
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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