Basic Information
VIS ID
TVIS44008831
Fusion event
HTLV-1-XRCC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q35
Reference genome
GRCh37/hg19
Start
217007256/216142533 (Hg38)
End
217007256/216142533 (Hg38)
Orient
+
Location type
Intronic
Target gene
XRCC5
miRNAs that regulate target gene
hsa-mir-484 ; hsa-mir-331-3p ; hsa-mir-7-5p ; hsa-mir-100-5p ; hsa-mir-26b-5p ; hsa-mir-7977 ; hsa-mir-4528 ; hsa-mir-584-5p ; hsa-mir-758-5p ; hsa-mir-218-2-3p ; hsa-mir-29b-1-5p ; hsa-mir-361-5p ; hsa-mir-92a-2-5p ; hsa-mir-3927-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-1324 ; hsa-mir-2115-3p ; hsa-mir-31-5p ; hsa-mir-526b-5p ; hsa-mir-623
Nearest miRNA
hsa-mir-10b/Upstream/2384374; hsa-mir-1244-1/Downstream/1757980;
Nearest TSS
ENST00000437798/Upstream/11823; ENST00000485763/Downstream/61483;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/32992, chr2-CpG: 85/Downstream/228769
Nearest cancer related gene
XRCC5(TSG, No orient, 0)
Upstream sequence
AAGGCAGAGATTGGATTAAGGTAAATTGGGGAAGTTGACAAGAGAGCTGACTTATGCTGAGGAAGGGGAGGGCTAGACCAAGGTTGAAGGAGAAAGGAAT
Downstream sequence
ATTCCAGTCCTGGATTCAGTTGATGACAGCAGGACATAGGCTTCTCTGACCCCCACAAAACTGAAAAAAAAATTATATAAGCAGCTTTTTAAGGCAAGCT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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