Basic Information
VIS ID
TVIS44008841
Fusion event
HTLV-1-EPHA3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p11.1
Reference genome
GRCh37/hg19
Start
89243770/89194620 (Hg38)
End
89243770/89194620 (Hg38)
Orient
-
Location type
Intronic
Target gene
EPHA3
Nearest miRNA
hsa-let-7g/Upstream/1968343; hsa-mir-12124/Downstream/7165344;
Nearest TSS
ENST00000440867/Upstream/86944; ENST00000478400/Downstream/4716537;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/79663, chr3-CpG: 39/Downstream/4779090
Nearest cancer related gene
EPHA3(TSG, No orient, 0)
Upstream sequence
AAGAAAGTTCTCCAATCTCCTATAGAATCTATTGAATATTTTTCTATTCAATAATAAAATTGTTAGGACAAAATCTCTGTATCTGCTTTGACTTCTTCTC
Downstream sequence
TGCTATGCTTTATGAAGTAAATGACGTTTTGTGAAAACCTCTGCTAACAAAAATACATGTATTTTTTATAGTCAATATCTGTCTTCTTGTCAGTTCACTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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