Basic Information
VIS ID
TVIS44008854
Fusion event
HTLV-1-PPWD1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q12.3
Reference genome
GRCh37/hg19
Start
64862339/65566512 (Hg38)
End
64862339/65566512 (Hg38)
Orient
+
Location type
Intronic
Target gene
PPWD1
miRNAs that regulate target gene
hsa-mir-361-3p ; hsa-mir-7153-5p ; hsa-mir-7641 ; hsa-mir-146b-5p ; hsa-mir-146a-5p ; hsa-mir-589-5p ; hsa-mir-4502 ; hsa-mir-4699-3p ; hsa-mir-4773 ; hsa-mir-4662a-5p ; hsa-mir-143-5p ; hsa-mir-3944-5p ; hsa-mir-548ax ; hsa-mir-548ao-5p ; hsa-mir-3622b-3p ; hsa-mir-3622a-3p ; hsa-mir-8066 ; hsa-mir-6768-3p ; hsa-mir-606 ; hsa-mir-340-5p ; hsa-mir-4423-3p ; hsa-mir-4775 ; hsa-mir-5590-3p ; hsa-mir-142-5p ; hsa-mir-3622a-5p ; hsa-mir-5582-5p ; hsa-mir-32-3p ; hsa-mir-561-3p ; hsa-mir-548at-5p ; hsa-mir-6875-3p ; hsa-mir-6883-3p ; hsa-mir-630 ; hsa-mir-4999-5p
Nearest miRNA
hsa-mir-10397/Upstream/5862809; hsa-mir-103a-1/Downstream/6602955;
Nearest TSS
ENST00000502646/Upstream/2624; ENST00000507608/Downstream/2851;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/3056, chr5-CpG: 30/Downstream/57575
Upstream sequence
gaagggtacactttttcaagacttcctgtgacaaaacatttccacttttactcattagcatatggttaaacctcactccaggggaaagtgagaaaggtca
Downstream sequence
tgttatatctggacatcagtatgcccatatataaatgggggttctgttcctaaaaatgaagggaaaagtagtttatcagacacaagcctgaaacagctcg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate