Basic Information
VIS ID
TVIS44008865
Fusion event
HTLV-1-PRIM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
57268913/57404115 (Hg38)
End
57268913/57404115 (Hg38)
Orient
+
Location type
Intronic
Target gene
PRIM2
miRNAs that regulate target gene
hsa-mir-665 ; hsa-mir-887-5p ; hsa-mir-6780a-5p ; hsa-mir-6779-5p ; hsa-mir-3689c ; hsa-mir-3689b-3p ; hsa-mir-3689a-3p ; hsa-mir-30b-3p ; hsa-mir-1273h-5p ; hsa-mir-6788-5p ; hsa-mir-30c-2-3p ; hsa-mir-30c-1-3p ; hsa-mir-4266 ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-7106-5p ; hsa-mir-6894-5p ; hsa-mir-7160-5p ; hsa-mir-202-3p ; hsa-mir-98-5p ; hsa-mir-4500 ; hsa-mir-4458 ; hsa-let-7i-5p ; hsa-let-7g-5p ; hsa-let-7f-5p ; hsa-let-7e-5p ; hsa-let-7d-5p ; hsa-let-7c-5p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-7162-3p ; hsa-mir-6500-3p ; hsa-mir-3614-5p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-4779 ; hsa-mir-4695-5p ; hsa-mir-890
Nearest miRNA
hsa-mir-10398/Upstream/13903; hsa-mir-10524/Downstream/13972845;
Nearest TSS
ENST00000381078/Upstream/24168; ENST00000421261/Downstream/89740;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/181602, chr6-CpG: 35/Downstream/449761
Upstream sequence
ACCTTATTACCTCTCAAAGGCCAATGGATATATTTGCTTGTTCTATTATTCATGGTAGTACTTAGCAAAGTGTTTTCTAAGAGGCTGTCTATAAAACTTA
Downstream sequence
CCAAGCAGGCCtcttcattttgcccatgaacgtctagcctcagaaaggttgagcggcctgcaagaactcacattgctcattagtgaaagacctgggtctt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate