Basic Information
VIS ID
TVIS44008867
Fusion event
HTLV-1-REPS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q24.1
Reference genome
GRCh37/hg19
Start
139248113/138926976 (Hg38)
End
139248113/138926976 (Hg38)
Orient
+
Location type
Intronic
Target gene
REPS1
miRNAs that regulate target gene
hsa-mir-423-5p ; hsa-mir-193b-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-6885-3p ; hsa-mir-653-5p ; hsa-mir-1273e ; hsa-mir-4452 ; hsa-mir-183-3p ; hsa-mir-1267 ; hsa-mir-4470 ; hsa-mir-8073 ; hsa-mir-3128 ; hsa-mir-221-5p ; hsa-mir-6749-3p ; hsa-mir-6509-3p ; hsa-mir-2116-3p ; hsa-mir-1273g-3p ; hsa-mir-181a-2-3p
Nearest miRNA
hsa-mir-10398/Upstream/491682; hsa-mir-1202/Downstream/1278276;
Nearest TSS
ENST00000381078/Upstream/10762; ENST00000461027/Downstream/3021;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/130644, chr6-CpG: 110/Downstream/60385
Upstream sequence
TGTACTGATTTTGTGATCCTAATGAATCAAAGTTTTGTTCAAAACAAAGCAAGTCAGTGCGACTTGCCAGTGCGACCCCTGAAAGATGATTCTATTATGT
Downstream sequence
ACGTGCACATATTTTACACATATGTATAGATATTTAATAAAATATAATTGAGATAAAATGCAAAGAATTCTGGAATTAATATATGTAGAGCTTATGTCAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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