Basic Information
VIS ID
TVIS44008877
Fusion event
HTLV-1-FBXO32 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr8
Cytoband
q24.13
Reference genome
End
124541720/123529480 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
Target gene
Nearest miRNA
hsa-mir-12123/Upstream/181350; hsa-mir-10400/Downstream/979035;
Nearest cancer related gene
FBXO32(TSG, No orient, 0)
Upstream sequence
GTAAGTGGGTAACAGTAAACATTAGCGGCTGACTTTGCACAGCAGATAGATTCTAGtgtccaaagtacttctgtttatatcactgagtttccccagctac
Downstream sequence
cccgggaagttgaggtaagtcattcttacagaggaggaaaccatgtcttagggaggttgagacagtttgaaatcagtggagctaggacctgccctcaggc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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