Basic Information
VIS ID
TVIS44008881
Fusion event
HTLV-1-FRMD3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr9
Cytoband
q21.32
Reference genome
GRCh37/hg19
Start
85946188/83331273 (Hg38)
End
85946188/83331273 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRMD3
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-377-3p ; hsa-mir-8064 ; hsa-mir-7110-3p ; hsa-mir-8485 ; hsa-mir-342-3p ; hsa-mir-6873-3p ; hsa-mir-6817-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-5007-3p ; hsa-mir-1279 ; hsa-mir-3613-3p
Nearest miRNA
hsa-mir-101-2/Upstream/12521189; hsa-let-7a-1/Downstream/638475;
Nearest TSS
ENST00000422679/Upstream/19307; ENST00000530832/Downstream/688;
Nearest CpG islands
None/Target, chr9-CpG: 64/Upstream/267867, chr9-CpG: 145/Downstream/206165
Upstream sequence
cataattgctcaaacttggaagcaaccaagatgtctttcagcaggtaaatggataaattatgatacatacagacaatggaatattattttatgccaaaag
Downstream sequence
gaaatgagctcttaaaccaagaaaagacatggaggaaacttaaatgcatattactgagtgaaagaagccaatctgaaaagactacacattgtatgattcc
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate