VISDB - VIS Detail

Basic Information

VIS ID

TVIS44008888

Fusion event

HTLV-1-ZBTB43 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr9

Cytoband

q33.3

Reference genome

GRCh37/hg19

Start

129586251/126823972 (Hg38)

End

129586251/126823972 (Hg38)

Orient

Location type

Intronic

Target gene

ZBTB43

miRNAs that regulate target gene

hsa-mir-193b-3p ; hsa-mir-142-5p ; hsa-mir-548k ; hsa-mir-3622a-3p ; hsa-mir-3622b-3p ; hsa-mir-5003-3p ; hsa-mir-5590-3p ; hsa-mir-548av-5p ; hsa-mir-8054 ; hsa-mir-500a-3p ; hsa-mir-501-3p ; hsa-mir-502-3p ; hsa-mir-4662a-3p ; hsa-mir-6804-3p ; hsa-mir-95-5p ; hsa-mir-580-5p ; hsa-mir-6765-3p ; hsa-mir-5692a ; hsa-mir-548l ; hsa-mir-559 ; hsa-mir-548y ; hsa-mir-548w ; hsa-mir-548o-5p ; hsa-mir-548j-5p ; hsa-mir-548i ; hsa-mir-548h-5p ; hsa-mir-548d-5p ; hsa-mir-548c-5p ; hsa-mir-548bb-5p ; hsa-mir-548b-5p ; hsa-mir-548ay-5p ; hsa-mir-548as-5p ; hsa-mir-548au-5p ; hsa-mir-548ar-5p ; hsa-mir-548aq-5p ; hsa-mir-548ap-5p ; hsa-mir-548am-5p ; hsa-mir-548ak ; hsa-mir-548ae-5p ; hsa-mir-548ad-5p ; hsa-mir-548ab ; hsa-mir-548a-5p ; hsa-mir-448 ; hsa-mir-153-3p ; hsa-mir-5587-5p ; hsa-mir-640 ; hsa-mir-378a-5p ; hsa-mir-6131 ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-3653-5p ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-4719 ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-7107-5p ; hsa-mir-1234-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-5006-5p ; hsa-mir-3972 ; hsa-mir-1202 ; hsa-mir-211-5p ; hsa-mir-204-5p ; hsa-mir-623 ; hsa-mir-3194-5p ; hsa-mir-1915-5p ; hsa-mir-6780b-3p ; hsa-mir-4780

Nearest miRNA

hsa-let-7a-1/Upstream/2130174; hsa-mir-12126/Downstream/866715;

Nearest TSS

ENST00000422679/Upstream/18939; ENST00000497064/Downstream/7437;

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/18448, chr9-CpG: 19/Downstream/9106

Upstream sequence

tctcctgtcccttcaccttcatgttgtcattgtcactgattatatctttatatattgtgtaatgtgtattaacataaatttataattgttttatgcattc

Downstream sequence

attagccttttaaatcatatagaaacaaaagaattaaaaaccaaaagtacaacaatgatggcttttttttttgagacagagtctcactctgttgcccagg

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.