Basic Information
VIS ID
TVIS44008917
Fusion event
HTLV-1-TNPO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q13.2
Reference genome
End
72203394/72907567 (Hg38)
Orient
-
Location type
Intronic
Target gene
miRNAs that regulate target gene
hsa-mir-210-3p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-34a-5p ; hsa-mir-21-5p ; hsa-mir-16-5p ; hsa-mir-92a-3p ; hsa-mir-18a-5p ; hsa-let-7b-5p ; hsa-mir-23a-3p ; hsa-mir-27a-3p ; hsa-mir-101-3p ; hsa-mir-181a-5p ; hsa-mir-181b-5p ; hsa-mir-181c-5p ; hsa-mir-23b-3p ; hsa-mir-27b-3p ; hsa-mir-130a-5p ; hsa-mir-144-3p ; hsa-mir-181d-5p ; hsa-mir-513a-5p ; hsa-mir-4262 ; hsa-mir-23c ; hsa-mir-4310 ; hsa-mir-7157-5p ; hsa-mir-648 ; hsa-mir-4468 ; hsa-mir-3591-5p ; hsa-mir-1245b-3p ; hsa-mir-548ao-5p ; hsa-mir-548ax ; hsa-mir-6081 ; hsa-mir-32-5p ; hsa-mir-92b-3p ; hsa-mir-139-5p ; hsa-mir-190a-3p ; hsa-mir-338-5p ; hsa-mir-640 ; hsa-mir-1277-5p ; hsa-mir-5011-5p ; hsa-mir-6074 ; hsa-mir-6076 ; hsa-mir-6797-3p ; hsa-mir-151a-3p ; hsa-mir-4426 ; hsa-mir-4647 ; hsa-mir-4662b ; hsa-mir-374a-5p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-548d-3p ; hsa-mir-548h-3p ; hsa-mir-3613-3p ; hsa-mir-548z ; hsa-mir-548ac ; hsa-mir-548bb-3p ; hsa-mir-4742-3p ; hsa-mir-20a-3p ; hsa-mir-466 ; hsa-mir-513a-3p ; hsa-mir-513c-3p ; hsa-mir-3606-3p ; hsa-mir-5585-5p ; hsa-mir-5096 ; hsa-mir-410-3p ; hsa-mir-3681-3p ; hsa-mir-216a-3p ; hsa-mir-128-3p ; hsa-mir-7702 ; hsa-mir-4775 ; hsa-mir-5588-5p ; hsa-mir-4799-3p ; hsa-mir-4720-5p ; hsa-mir-6868-5p ; hsa-mir-8083 ; hsa-mir-3128 ; hsa-mir-3191-5p ; hsa-mir-6728-3p ; hsa-mir-142-3p ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-4428 ; hsa-mir-802 ; hsa-mir-8485 ; hsa-mir-7-2-3p ; hsa-mir-7-1-3p ; hsa-mir-5688 ; hsa-mir-495-3p ; hsa-mir-4668-5p ; hsa-mir-103a-2-5p ; hsa-mir-607 ; hsa-mir-3671 ; hsa-mir-505-3p ; hsa-mir-140-3p ; hsa-mir-195-3p ; hsa-mir-16-2-3p ; hsa-mir-6739-3p ; hsa-mir-4677-5p ; hsa-mir-7156-5p ; hsa-mir-4273 ; hsa-mir-192-3p ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-942-5p ; hsa-mir-1273g-3p ; hsa-mir-1285-3p ; hsa-mir-196a-3p ; hsa-mir-3187-5p ; hsa-mir-4252 ; hsa-mir-4793-3p ; hsa-mir-508-5p ; hsa-mir-5189-5p ; hsa-mir-612 ; hsa-mir-6512-3p ; hsa-mir-661 ; hsa-mir-6720-5p ; hsa-mir-6849-3p ; hsa-mir-6860 ; hsa-mir-766-3p ; hsa-mir-7703 ; hsa-mir-939-3p
Nearest miRNA
hsa-mir-10397/Upstream/28904; hsa-mir-103a-1/Downstream/9932588;
Upstream sequence
TTCTACACAGATGGATTAACTGCCCTCTGTGAATTCACATGAACGTTCATAAATGGCCAAAACTTGGCATGATTGGGTAGTAGAGTTCTGTTTGTAAAAG
Downstream sequence
GACCACTATCAGGTAACAGTTTAAATCTCCCAGTAATCTTACCTTATTTCTTAATATCCTTTTTATCATTAAAACTGTTTAGCATAGAAAAAAGTTCCTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate