Basic Information
VIS ID
TVIS44008918
Fusion event
HTLV-1-chr6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p22.2
Reference genome
GRCh37/hg19
Start
26569431/26569203 (Hg38)
End
26569431/26569203 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6C
Nearest miRNA
hsa-mir-3691/Upstream/7997323; hsa-mir-10398/Downstream/578423;
Nearest TSS
ENST00000381078/Upstream/30765; ENST00000641660/Downstream/121;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/18317, chr6-CpG: 28/Downstream/26615
Nearby gene
HMGN4(+22267) ;
Upstream sequence
ACGCGCCATCAAGACTTCATCCCTATAATTCGTATAATCCAACCCTCTTAGAAGCCCTGGGCACTGAGGAAGTGAATCAGACACTGGTCCACTGGGCTAG
Downstream sequence
AGATCCACAGAGGCGTCTCCACCCCTCAACCCCGGATCCACAGCCGGGGGAAAGGGGCGGCTGGTGGGAATTACTCGGAGCAACTGGTAATTGGTGGGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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