Basic Information
VIS ID
TVIS44008919
Fusion event
HTLV-1-HSF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q22.31
Reference genome
GRCh37/hg19
Start
122752053/122430908 (Hg38)
End
122752053/122430908 (Hg38)
Orient
+
Location type
Intronic
Target gene
HSF2
miRNAs that regulate target gene
hsa-mir-18a-5p ; hsa-mir-26b-5p ; hsa-mir-24-3p ; hsa-let-7b-5p ; hsa-let-7a-5p ; hsa-mir-1324 ; hsa-mir-190a-3p ; hsa-mir-2115-3p ; hsa-mir-361-5p ; hsa-mir-3927-5p ; hsa-mir-4487 ; hsa-mir-454-5p ; hsa-mir-4633-3p ; hsa-mir-4802-5p ; hsa-mir-5011-5p ; hsa-mir-6500-5p ; hsa-mir-6514-5p ; hsa-mir-652-5p ; hsa-mir-6874-5p ; hsa-mir-8076
Nearest miRNA
hsa-mir-10398/Upstream/2415651; hsa-mir-1202/Downstream/4053723;
Nearest TSS
ENST00000381078/Upstream/8752; ENST00000607474/Downstream/40914;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/30687, chr6-CpG: 28/Downstream/40705
Upstream sequence
CCTACCACAGTCAGATGTGAGGAGAGAAGAAAGTGGTTCAAAGAAGCAATTTAAATGACAGAAAAGAACTGACAGAGCTACAGAAAGGACAAGAAGAAAC
Downstream sequence
ACCACCTCAACTTTGAGGCTTCTAAATAGTGATAAAGAGTTTTAAGGATGTCATTATGTCATCCTGAGCTACTCTAAATATGTTCACTTATGCTAAATAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate