Basic Information
VIS ID
TVIS44008930
Fusion event
HTLV-1-TCP11L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p13
Reference genome
GRCh37/hg19
Start
33096052/33074506 (Hg38)
End
33096052/33074506 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11E
Target gene
TCP11L1
miRNAs that regulate target gene
hsa-mir-92b-3p ; hsa-mir-3124-3p ; hsa-mir-8087 ; hsa-mir-7161-5p ; hsa-mir-548u
Nearest miRNA
hsa-mir-210/Upstream/4596958; hsa-let-7a-2/Downstream/1867331;
Nearest TSS
ENST00000527297/Upstream/5819; ENST00000631190/Downstream/1643;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/34206, chr11-CpG: 24/Downstream/86935
Nearby gene
TCP11L1(+943) ;
Upstream sequence
GTATTCCAATAGGACTGATGGGGAGGAAATCAGATACTCCATGAGAAGGATTTCAGACCTGGTAGAGTCAGAATACATTCTGCTTTCAGGATTTTTGAGA
Downstream sequence
TTGCTGATGGTCCCAGGGTTTATACAAGGACTTGGATCTGGCTATAGAAACTCAGGTAGAAATTACATGTATGCAGATCAGCACTGATGTTGGTTCTAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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