Basic Information
VIS ID
TVIS44008957
Fusion event
HTLV-1-LYPD6B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q23.2
Reference genome
GRCh37/hg19
Start
150053121/149196607 (Hg38)
End
150053121/149196607 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LYPD6B
miRNAs that regulate target gene
hsa-mir-218-5p
Nearest miRNA
hsa-mir-128-1/Upstream/8609922; hsa-mir-10b/Downstream/133671;
Nearest TSS
ENST00000437798/Upstream/54571; ENST00000280115/Downstream/7918;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/157313, chr2-CpG: 38/Downstream/123692
Upstream sequence
CCTAGGACAGAAGTAAAAAGACAGGACAGATGCATAGTAACAATTCTGCATCGTGCAGCTCTCCCAGTTGAAAGATAACCATGTGGGTGCTGAAGGCAGT
Downstream sequence
TGAGATTATAGGGAATACTGTCTCCTAAACAGAGTTCTAGGGACAATTTTACAATCTGGCACACAGTGCTTAAGCAATGAATTCATTCAATAAAATATAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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