Basic Information
VIS ID
TVIS44008967
Fusion event
HTLV-1-LYST integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q42.3
Reference genome
GRCh37/hg19
Start
236024309/235861009 (Hg38)
End
236024309/235861009 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA1H
Target gene
LYST
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-93-5p ; hsa-mir-92b-3p ; hsa-mir-193a-3p ; hsa-mir-26a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/7949; hsa-mir-3123/Downstream/1610110;
Nearest TSS
ENST00000473358/Upstream/21526; ENST00000366591/Downstream/5867;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/209821, chr1-CpG: 113/Downstream/5278
Upstream sequence
cattttctagaattttacagatggaacaatgcagtatgtactttttttttctttttggtctggctttttttcgtgctgtgtaattattttgagatttatc
Downstream sequence
catgttgttgtgtgatctaaagttcattccttgttattgctaagtagtaatctgttatataaacatTGCTTTTTAAAGATGAGTGGCAGTAGTTTTATAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate