Basic Information
VIS ID
TVIS44008971
Fusion event
HTLV-1-EDIL3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q14.3
Reference genome
GRCh37/hg19
Start
83329729/84033910 (Hg38)
End
83329729/84033910 (Hg38)
Orient
-
Location type
Intronic
Target gene
EDIL3
miRNAs that regulate target gene
hsa-mir-21-5p ; hsa-mir-377-3p ; hsa-mir-676-5p ; hsa-mir-3691-3p ; hsa-mir-1228-3p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-1264 ; hsa-mir-4668-5p ; hsa-mir-4328 ; hsa-mir-548t-3p ; hsa-mir-548ap-3p ; hsa-mir-548aa ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-7154-5p ; hsa-mir-8060
Nearest miRNA
hsa-mir-10397/Upstream/1193686; hsa-mir-103a-1/Downstream/3080969;
Nearest TSS
ENST00000502646/Upstream/312297; ENST00000507060/Downstream/44918;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/311371, chr5-CpG: 25/Downstream/348409
Upstream sequence
GCTATCACCTGATAGTTACACTCTGTGGGATATATTAAGTTAGTGATCTGGACTCTGAGTTGTATGTGACGTTACACTTTAATATGACAGTTAGACAACA
Downstream sequence
AAGATAGGAAACTCTTCAGGGAGGGAATAGGGGGCACTAGCTGGCCAGTGGCTGTGATCAATCCAGGACAAAGCAGGGCAAGATTCTGAGCTCACAGGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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