Basic Information
VIS ID
TVIS44008992
Fusion event
HTLV-1-MEX3C integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.2
Reference genome
GRCh37/hg19
Start
48720004/51193634 (Hg38)
End
48720004/51193634 (Hg38)
Orient
-
Location type
Intronic
Target gene
MEX3C
miRNAs that regulate target gene
hsa-mir-374b-5p ; hsa-mir-103a-3p ; hsa-mir-744-5p ; hsa-mir-155-5p ; hsa-mir-4659a-3p ; hsa-mir-4659b-3p ; hsa-mir-4724-5p ; hsa-mir-4793-5p ; hsa-mir-5196-3p ; hsa-mir-6875-3p ; hsa-mir-8064
Nearest miRNA
hsa-mir-1-2/Upstream/1067071; hsa-mir-122/Downstream/2043467;
Nearest TSS
ENST00000575820/Upstream/116383; ENST00000578152/Downstream/3125;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/162671, chr18-CpG: 156/Downstream/2526
Upstream sequence
ACAGAGACGTTCTAAGTTTATAAAATTAGGTCTTAAAATCTGTTGTCAGGTTTATTTTTGATGTCCATATTCTAAAACTTCTTTGATTATATCAACAAGC
Downstream sequence
CTCTTCAGTTCCTGGCTTTATTTTACAGTATTGTTGTTTCACAACAGATGCAATGCTTTAAAAAACAAGGCCAATTTAACATTTACAAATGACCATATGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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