Basic Information
VIS ID
TVIS44008996
Fusion event
HTLV-1-LOC105373754 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
177478896/176614168 (Hg38)
End
177478896/176614168 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2G
Target gene
LOC105373754
Nearest miRNA
hsa-mir-10b/Upstream/13116; hsa-mir-1244-1/Downstream/598558;
Nearest TSS
ENST00000437798/Upstream/1919; ENST00000443670/Downstream/23394;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/123452, chr2-CpG: 79/Downstream/23545
Nearby gene
MIR1246(-13116) ;
Upstream sequence
acttcaaaataccagcgacttcacacaacagaagtttctctctcactcagataacaatccaaagcagatgttccttatctgtgggaggttttcctccatg
Downstream sequence
tggtgataaaggattcagccttctctcttgaggcttggcttttccctatggcttcagaatcATTTCCAGTCCCCAGAGATACTGGAAAAGGCACAGCCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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