Basic Information
VIS ID
TVIS44009001
Fusion event
HTLV-1-TMEM165 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
q12
Reference genome
GRCh37/hg19
Start
56283553/55417386 (Hg38)
End
56283553/55417386 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4B
Target gene
TMEM165
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-769-5p ; hsa-mir-17-5p ; hsa-let-7c-5p ; hsa-let-7a-5p
Nearest miRNA
hsa-mir-12113/Upstream/2704639; hsa-mir-1243/Downstream/5505233;
Nearest TSS
ENST00000502981/Upstream/257; ENST00000509575/Downstream/305;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/21050, chr4-CpG: 144/Downstream/128440
Upstream sequence
CAACTAGGAATAAACACTCTACAGAGGTTTCTCAGTGGCCCCATCTGTGTGATATGCGGGGCTACACAAAAATAGCTTCTTTTGCTTTGTTCTGTTCTTA
Downstream sequence
TACCTGTCTGTGATCTGACTTGGGGTTGGTGTGAATGTAGTAGAGAAAGGAAGCTGACAGATGAATACTGAACACAGGTAAtcagtttccttaattaggt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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