Basic Information
VIS ID
TVIS44009009
Fusion event
HTLV-1-LY86-AS1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p25.1
Reference genome
GRCh37/hg19
Start
6591708/6591475 (Hg38)
End
6591708/6591475 (Hg38)
Orient
+
Location type
ncRNA_intronic
Fragile sites / regions
FRA6B
Target gene
LY86-AS1
Nearest miRNA
hsa-mir-3691/Upstream/422040; hsa-mir-10398/Downstream/3848242;
Nearest TSS
ENST00000381078/Upstream/2806; ENST00000423568/Downstream/31220;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/44478, chr6-CpG: 132/Downstream/459788
Upstream sequence
AATTAAGCAACAGGGTAAATGCTTTGTGTGAAAGGCTGTAGTGAAGGCAGGCATTGTGCACCAGGGACATAGTAGTCAGACGATGGTGAGGTTGGTATCT
Downstream sequence
GGATCTGTTGGAAAAGGAGTCACCAAGCCTAAGTTGAGGCTTAAAGACTGATGAAAATACTAATGATAACACCTCATGTTGGTGGAGGCCACCAGGCTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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