Basic Information
VIS ID
TVIS44009012
Fusion event
HTLV-1-IRAK1BP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
79627356/78917639 (Hg38)
End
79627356/78917639 (Hg38)
Orient
-
Location type
Intronic
Target gene
IRAK1BP1
miRNAs that regulate target gene
hsa-mir-759 ; hsa-mir-892c-5p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181b-5p ; hsa-mir-181a-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-7703 ; hsa-mir-25-5p ; hsa-mir-196a-3p ; hsa-mir-658 ; hsa-mir-661 ; hsa-mir-6499-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-4537 ; hsa-mir-6860 ; hsa-mir-612 ; hsa-mir-5189-5p ; hsa-mir-3187-5p ; hsa-mir-1285-3p ; hsa-mir-4793-3p ; hsa-mir-766-3p ; hsa-mir-939-3p ; hsa-mir-6849-3p ; hsa-mir-1273g-3p ; hsa-mir-508-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-451b ; hsa-mir-6501-3p ; hsa-mir-6512-3p ; hsa-mir-6720-5p
Nearest miRNA
hsa-mir-10398/Upstream/378330; hsa-mir-1202/Downstream/11395103;
Nearest TSS
ENST00000381078/Upstream/19447; ENST00000604516/Downstream/65304;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/6639, chr6-CpG: 131/Downstream/159456
Nearby gene
IRAK1BP1(+16673) ;
Upstream sequence
ccagatacaagaaattcagagaacacctgtgagatactatacaaaatgaacattgccaaggcatatagtcaccagactgtcaaagtcaacactaaaaaaa
Downstream sequence
aaaaaaaaaaaaaaaaatcttaaaggcaactactgaaaaaggtcagatacatacaaagagaattccatcagactaacagtagacttctcagcagaaagct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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