Basic Information
VIS ID
TVIS44009014
Fusion event
HTLV-1-DAGLB integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
6462755/6423124 (Hg38)
End
6462755/6423124 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
DAGLB
miRNAs that regulate target gene
hsa-mir-193b-3p ; hsa-mir-186-5p
Nearest miRNA
hsa-mir-339/Upstream/711214; hsa-mir-10399/Downstream/643840;
Nearest TSS
ENST00000635602/Upstream/321; ENST00000489138/Downstream/24808;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1291, chr7-CpG: 53/Downstream/24551
Upstream sequence
gtggatggctacagcccaggagtccaagaccagcctgggcaacatagtgagatcctgtctctacaaaaatagaaaaaattagctgggtgtagtggcacat
Downstream sequence
gcctgtattcccagctacttgagaggctgaggcaggaggatcacttgagcccaagaggtggaggctgcagtgagctgactgtaccatcgtactccaccct
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate