VISDB - VIS Detail

Basic Information

VIS ID

TVIS44009040

Fusion event

HTLV-1-STX7 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr6

Cytoband

q23.2

Reference genome

GRCh37/hg19

Start

132822507/132501368 (Hg38)

End

132822507/132501368 (Hg38)

Orient

Location type

Intronic

Target gene

STX7

miRNAs that regulate target gene

hsa-mir-192-5p ; hsa-mir-30a-5p ; hsa-mir-215-5p ; hsa-mir-193b-3p ; hsa-mir-4776-3p ; hsa-mir-192-3p ; hsa-mir-4480 ; hsa-mir-6757-5p ; hsa-mir-6516-5p ; hsa-mir-1273f ; hsa-mir-455-3p ; hsa-mir-6499-3p ; hsa-mir-4468 ; hsa-mir-1228-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1273g-3p ; hsa-mir-4482-3p ; hsa-mir-5089-5p ; hsa-mir-377-3p ; hsa-mir-4320 ; hsa-mir-26a-2-3p ; hsa-mir-26a-1-3p ; hsa-mir-6731-3p ; hsa-mir-216b-3p ; hsa-mir-6871-5p ; hsa-mir-8054 ; hsa-mir-548k ; hsa-mir-548av-5p ; hsa-mir-548n ; hsa-mir-4793-3p ; hsa-mir-5690 ; hsa-mir-410-3p ; hsa-mir-3163 ; hsa-mir-890 ; hsa-mir-5582-5p ; hsa-mir-8485 ; hsa-mir-6771-5p ; hsa-mir-7160-5p ; hsa-mir-4722-5p ; hsa-mir-6884-5p ; hsa-mir-485-5p ; hsa-mir-1827 ; hsa-mir-4649-3p ; hsa-mir-6746-5p ; hsa-mir-665 ; hsa-mir-4768-3p ; hsa-mir-4478 ; hsa-mir-4419b ; hsa-mir-3929 ; hsa-mir-7977 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-4799-5p ; hsa-mir-1185-2-3p ; hsa-mir-1185-1-3p ; hsa-let-7f-2-3p ; hsa-mir-4789-5p ; hsa-mir-6793-3p ; hsa-mir-153-5p ; hsa-mir-1250-3p ; hsa-mir-543 ; hsa-mir-382-3p ; hsa-mir-6842-3p ; hsa-mir-647 ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-27a-5p ; hsa-mir-600 ; hsa-mir-4438 ; hsa-mir-6807-5p

Nearest miRNA

hsa-mir-10398/Upstream/386105; hsa-mir-1202/Downstream/2477970;

Nearest TSS

ENST00000381078/Upstream/99823; ENST00000434551/Downstream/11694;

Nearest CpG islands

None/Target, chr6-CpG: 120/Upstream/99606, chr6-CpG: 56/Downstream/11291

Upstream sequence

gtctcgaactcctgacctcccgtgatctgcctgcctcggcctcccaaagtgctgggattacaggtgtgagccaccatgccctgccaacagtcccagtctt

Downstream sequence

cttaacagctcttcacatagactgtggagtatcatagccagaccttcacatgatccaatactgccccggatgtactcGCACACTTAGCTACCAACCTGCC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.