Basic Information
VIS ID
TVIS44009046
Fusion event
HTLV-1-CDKL5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
p22.13
Reference genome
GRCh37/hg19
Start
18664749/18646629 (Hg38)
End
18664749/18646629 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDKL5
miRNAs that regulate target gene
hsa-mir-222-3p
Nearest miRNA
hsa-mir-3690-1/Upstream/1220675; hsa-let-7f-2/Downstream/1370459;
Nearest TSS
ENST00000429181/Upstream/58943; ENST00000486029/Downstream/3908;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/220323, chrX-CpG: 55/Downstream/28403
Upstream sequence
acagcatgaacatgtatgctaactaatacgcactcagggtcctcccattatccctacagtacggaccacagtcattaacgtggcttctaaggtcctgcac
Downstream sequence
catctgacctccgcttgcctctccaccttgtctcacttgtgcttcaggcttgctgccctgcttatgttccccatccacaccctggaggtatcatcccgac
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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